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Chronic Lymphocytic Leukaemia: A Test of a Proposed New Clinical Staging System
Author(s) -
Geisler C.,
Hansen M. Mørk
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb00485.x
Subject(s) - lymphocytosis , medicine , stage (stratigraphy) , staging system , platelet , lymph , chronic lymphocytic leukemia , gastroenterology , pathology , leukemia , cancer , paleontology , biology
102 patients with chronic lymphocytic leukaemia underwent clinical staging according to 2 systems: the Rai staging system with 5 stages (0: lymphocytosis, I: palpable lymph nodes, II: hepato‐ or splenomegaly, III: Hb below 110 g/1, IV: platelet count below 100 times 10 9 /1) was compared to a staging system recently proposed by Binet, with only 3 stages (A: not more than 2 areas of palpable nodes or organs, B: at least 3 areas, C: Hb below 10 g/1 or platelet count below 100 times 19 9 /1). With the 3‐stage system statistically significant differences between the stages were obtained, whereas some of the Rai stages (I‐II‐III) were only poorly separated. Non‐haemolytic anaemia with Hb below 100 g/1 was associated with a far graver prognosis than milder anaemia (Hb between 100 and 110 g/1) or auto‐immune haemolytic anaemia. Chest X‐ray findings did not influence the clinical stage.