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Monocyte Cytotoxicity after Splenectomy
Author(s) -
Kragballe Knud,
Nielsen Johan Lanng,
Sølling Jacob,
Ellegaard Jørgen
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb00484.x
Subject(s) - antibody dependent cell mediated cytotoxicity , monocyte , cytotoxicity , splenectomy , immunology , medicine , spleen , immune system , in vitro , antibody , biology , biochemistry , monoclonal antibody
Antibody‐dependent cell‐mediated cytotoxicity (ADCC) by monocytes was determined in 45 adults approximately 4 years after splenectomy for either abdominal trauma or accidental injury during operation for benign gastroduodenal ulcer. Compared to controls, both groups of splenectomized persons showed increased numbers of monocytes and decreased monocyte ADCC. The decrease of monocyte ADCC was only significant in those splenectomized persons in whom accessory splenic tissue was not detectable by isotope scanning. Addition of the spleen‐dependent peptide tuftsin to monocytes in vitro did not augment their ADCC. An increased serum concentration of immune complexes was demonstrated in 18 % of the splenectomized persons, but this increase was neither releated to the presence of splenic tissue nor to the monocyte cytotoxicity. Vaccination with pneumococcal polysaccharide had no effect on monocyte ADCC. It is suggested that the defective monocyte cytotoxicity observed in splenectomized persons without detectable splenic tissue might be relevant to post splenectomy infectious susceptibility.