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Spontaneous Immunoglobulin Changes in Human Plasma‐Cell Dyscrasia
Author(s) -
Carter A.,
Spira G.,
Manaster J.,
Tatarsky I.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb00460.x
Subject(s) - plasma cell dyscrasia , immunoglobulin light chain , plasma cell , dyscrasia , paraproteinemias , antibody , multiple myeloma , monoclonal , immunoglobulin d , immunoglobulin a , myeloma protein , gammopathy , monoclonal antibody , immunoglobulin g , monoclonal gammopathy of undetermined significance , plasmacytoma , immunoglobulin e , immunoglobulin m , bence jones protein , immunology , medicine , b cell
A series of spontaneous changes affecting the nature of the immunoglobulin secretion of plasma cells is described in a patient initially diagnosed as IgG lambda benign monoclonal gammopathy. After several years a slight increase in the amount of serum monoclonal immunoglobulin occurred; shortly thereafter an aggressive form of multiple myeloma was diagnosed. Unexpectedly a rapid spontaneous decrease of the monoclonal immunoglobulin, accompanied by the appearance in the serum of increasing quantities of a complex containing intact lambda light chains, then occurred. Concomitantly a fragment of the corresponding free light chain was detected in the urine. A parallel is drawn between the facts observed in this patient and in an animal model recently proposed to explain the different types of structural immunoglobulin abnormalities in multiple myeloma.