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Clones with 5q—and Inversion of Chromosome 7 in PHA Stimulated Peripheral Blood
Author(s) -
Leeksma C. H. W.,
Nijs J. Den,
Havik F.,
Kerkhofs H.,
Geraedts J. P. M.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb00446.x
Subject(s) - chromosomal inversion , mitosis , peripheral blood , bone marrow , myeloid , peripheral , biology , immunology , precursor cell , stem cell , chromosome , microbiology and biotechnology , cell , medicine , karyotype , genetics , gene
In a patient with autoimmune thrombocytopenic purpura, 2 distinct clonal abnormalities, deletion 5q and inversion 7, could be demonstrated in phytohaemagglutin stimulated peripheral blood. A large number of bone marrow mitosis was normal while unstimulated peripheral blood revealed no metaphases. The mutational events leading to the aberrations might have taken place in lymphoid precursor cells or in a pluripotential stem cell that lost the capacity to develop in the myeloid direction.