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β 2 ‐Microglobulin in Chronic Lymphocytic Leukaemia
Author(s) -
Simonsson B.,
Wibell L.,
Nilsson K.
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb02364.x
Subject(s) - beta 2 microglobulin , beta (programming language) , lymphocyte , medicine , thymidine , immunology , peripheral blood , in vitro , mean value , gastroenterology , peripheral blood lymphocyte , chemistry , biochemistry , statistics , mathematics , computer science , programming language
The serum level of β 2 ‐microglobulin (S‐β 2 m), a cell membrane protein associated with HLA‐antigens, was quantitated in a series of 23 consecutive patients with chronic lymphocytic leukaemia (CLL). Markedly elevated values of S‐β 2 m (> 4.5 mg/l) were found in 10 patients, while only 3 patients had normal values (< 3.0 mg/l). High serum values correlated with a large tumour mass, as estimated by Rai's clinical staging and by the total peripheral lymphocyte count. Blood lymphocyte proliferative activity, which has been suggested as reflecting disease activity in CLL, was measured by 3 H‐thymidine uptake in cells in vitro. The 3 H‐thymidine uptake was high in 3 patients all of whom were among the 5 patients with the highest S‐β 2 m‐values. S‐β 2 m‐determinations seem to be of definite interest in the study of patients with CLL although long term studies will be necessary for evaluation of the practical clinical value.