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Presence of a Non‐Splenic Platelet Pool in Man
Author(s) -
Vilén Lars,
Fredén Krister,
Kutti Jack
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb02357.x
Subject(s) - platelet , spleen , medicine , immunology
3 asplenic but otherwise healthy men, in whom autologous platelets had been labelled with radioactive sodium chromate, received i.v. infusions of epinephrine in a dose of 0.35 μg per kg per min over a period of 20 min. In response to these infusions an increase in the concentration of labelled platelets (average 8% over the basal value) was seen in all 3 subjects. In no case was the maximal increase in the venous haematocrit higher than 1%. Identical experiments were also carried out on 3 intact male volunteers. As compared to the asplenics, the mean maximal increase in platelet‐bound radioactivity was considerably higher (41%). It is concluded that a small but significant epinephrine sensitive non‐splenic platelet pool is present in humans.