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Prognostic Significance of Amoeboid Movement Configuration in Lymphoid Cells from Children with Acute Lymphoblastic Leukaemia
Author(s) -
Sjögren U.,
Garwicz S.
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01592.x
Subject(s) - lymphoblast , bone marrow , mitosis , clone (java method) , rosette formation , precursor cell , biology , medicine , pathology , immunology , cell , antibody , cell culture , microbiology and biotechnology , genetics , dna
Bone marrow smears from 72 consecutive children with a recent diagnosis of acute lymphoblastic leukaemia (ALL) have been morphologically analyzed. A high incidence of lymphoid cells with amoeboid movement configuration (AMC) seems to indicate a more favorable prognosis independently of other prognostic factors e.g. age, WBC or sex. A positive correlation between the AMC and the mitotic indices (MI) of the lymphoblasts indicates some connection between the motility and the proliferative activity of the leukaemic cell clone.