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Growth Patterns of Human Acute Lymphoblastic Leukaemia in Diffusion Chambers before Treatment and after Cessation of Therapy
Author(s) -
Fontebuoni Anna,
Izzi Teodosio,
Lucarelli Guido
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01327.x
Subject(s) - medicine , bone marrow , chronic myeloid leukaemia , chemotherapy , oncology
Diffusion Chambers (DC) were used to culture human bone marrow of ALL patients at the beginning and after the cessation of therapy. No growth was observed in patients before treatment, while growth patterns similar to the normal were obtained in patients after 3 years of maintenance therapy. We suggested the possibility of intensifying the multiple drug chemotherapy in ALL without permanent damage of the stem cell proliferative compartment.