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Suppressor T‐Lymphocytes and Auto‐Anti‐B‐Cell Cytotoxic T‐Lymphocytes in a Case of Acquired Hypogammaglobulinaemia
Author(s) -
Kristensen Tom,
Nielsen Johan Lanng,
Ellegaard Jørgen
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01322.x
Subject(s) - cytotoxic t cell , immunology , pathogenesis , suppressor , cytotoxicity , t lymphocyte , lymphocyte , biology , immune system , in vitro , cancer , biochemistry , genetics
A case of acquired hypogammaglobulinaemia has been examined. Total and differential leucocyte counts and distribution were normal as were the lymphocyte sub‐populations when defined by surface membrane immunoglobulin, E‐, EA‐ and EAC‐rosette techniques. The proliferative response of unseparated lymphocytes to PHA and Con‐A was normal while the response to PWM was clearly impaired. In contrast, testing of purified B‐lymphocytes by PWM was within the normal range. The response to PWM was found to be depressed by adding the patient's T‐lymphocytes to autologous B‐lymphocytes as well as to B‐lymphocytes from 10 normal, healthy controls. The patient's T‐lymphocytes were further tested for cytotoxicity against autologous B‐lymphocytes and B‐lymphocytes from the 10 control individuals. Cytotoxicity was observed against autologous B‐lymphocytes and against the B‐lymphocytes of 3 controls. These findings indicate the presence of peripherally circulating unspecific T‐suppressor lymphocytes and cytotoxic T‐lymphocytes of some immunogenetic specificity. The suppressor and cytotoxic T‐lymphocytes may separately or in combination be involved in the pathogenesis of hypogammaglobulinaemia. Thus, these findings are equivocal but underline the immunologic aspects of the pathogenesis.