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Extravascular Phagocytosis of Proerythrocytes following 5‐Fluorouracil
Author(s) -
Radley J. M.
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01321.x
Subject(s) - phagocytosis , organelle , bone marrow , compartment (ship) , population , vesicle , electron microscope , microbiology and biotechnology , ultrastructure , biology , chemistry , immunology , anatomy , medicine , biochemistry , membrane , oceanography , physics , environmental health , optics , geology
Amongst the perturbations induced in mouse bone marrow by 5‐fiuorouracil are the retention and phagocytosis of proerythrocytes within the extravascular compartment. Reasons for the latter response have been sought using electron microscopy. Proerythrocytes undergo normal maturation after 5‐fluorouracil, judged by loss of mitochondria and vesicles, but fail generally to attain a biconcave shape. Most proerythrocytes have lost their organelles before phagocytosis occurs. Quantitative light microscopy shows a rise in the number of proerythrocytes 1 d after 5‐fluorouracil which is attributable to maturation of orthochromatic erythroblasts. Thereafter the population size declines concomitantly with increased engulfment and phagocytosis by macrophages, activity which is maximal on days 4–5. Extravascular loss of proerythrocytes is also observed when marrow is rendered hypocellular by x‐irradiation, or hydroxyurea. It is suggested that excessive maturation of proerythrocytes in the extravascular compartment can lead to their phagocytosis.