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Platelet Aggregation in Neonates with Hyperbilirubinaemia
Author(s) -
Hiçsönmez Gönül,
ProzorovaZamani Vahide
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01320.x
Subject(s) - epinephrine , platelet , bilirubin , platelet aggregation , kernicterus , medicine , adenosine diphosphate , jaundice , endocrinology , adenosine
In 19 jaundiced newborns who had no evidence of kernicterus the effect of bilirubin on adenosine‐5′‐diphosphate (ADP), epinephrine and collagen‐induced platelet aggregation was studied. Compared to 20 normal adult controls, no significant difference was found for ADP and collagen‐induced platelet aggregation in jaundiced infants. However, with epinephrine, significantly decreased aggregation was observed, but this was also the case for non‐jaundiced infants. This suggests that the reduced response to epinephrine in hyperbilirubinaemic infants is related to age rather than to bilirubin. Increased bilirubin is therefore not responsible for any increased bleeding tendency due to impaired platelet function.