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2 Translocations, t(11;14) and t(l;6), in a Patient with Plasma Cell Leukaemia and 2 Populations of Plasma Cells
Author(s) -
Gahrton Gösta,
Zech Lore,
Nillsson Kenneth,
Lönnqvist Berit,
Carlström Anders
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01315.x
Subject(s) - immunoglobulin light chain , chromosomal translocation , kappa , population , bone marrow , microbiology and biotechnology , monoclonal antibody , plasma cell , antibody , cell , immunology , biology , chemistry , medicine , genetics , gene , linguistics , philosophy , environmental health
2 translocations, t(11;14) and t(1;6), were found in 24 out of 46 metaphases in bone marrow cells from an untreated patient with plasma cell leukaemia. The predominating cell population produced only kappa chains while a minute population produced IgG kappa. All serum Ig's were low and only minimal amounts of monoclonal IgG kappa were found in the serum and very small amounts of kappa light chains in the urine. Analyses of ours and 2 other reported patients indicated the possibility that the location of breakpoints on the chromosomes may be of etiologic importance for the type of light chain and perhaps for the class of heavy chain.