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Development of Factor VIII Antibody in Haemophilic Monozygotic Twins
Author(s) -
Frommel D.,
Panicucci F.,
Baicchi U.,
Chiara S.,
Mannucci P. M.,
Ruggeri Z.,
Muller J. Y.,
Allain J. P.,
Seger Janine,
Mercuriali F.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02856.x
Subject(s) - concordance , antibody , immunology , medicine , immune system , haemophilia a , blood transfusion , haemophilia , pediatrics
The immunologic consequences of replacement therapy have been studied in 2 pairs of young haemophilic monozygotic twins. In both pairs one cotwin only developed a factor VIII specific antibody. This non‐concordance illustrates the influence upon a specific immune response of non‐genetic factors since the blood products, administered to each brother‐pair, were not at all time identical nor were the regimens of transfusion therapy.