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Periodic Acid‐Schiff Reaction Changes During the Course of Relapsing Lymhpoblastic Leukaemia
Author(s) -
Lilleyman J. S.,
Britton J. A.,
Sugden P. J.,
Hoyle B. J.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02849.x
Subject(s) - lymphoblast , bone marrow , periodic acid–schiff stain , stage (stratigraphy) , immunology , disease , medicine , pathology , gastroenterology , biology , genetics , paleontology , cell culture , immunohistochemistry
Bone marrow smears taken at diagnosis and subsequent haematological relapse from 41 patients with lymphoblastic leukaemia (ALL) were compared to assess the proportion of blast cells showing a positive periodic acid‐Schiff (PAS) reaction at different stages of the same disease. 20 patients never displayed more than 10% PAS positive blasts at any stage, and of these 8 never had any PAS positivity at all. 7 patients maintained a proportion of PAS positive cells over 10 % of the total but with no loss or gain in the numbers of such cells. 14 patients showed a significant change in the PAS reaction during the course of their disease, 7 showing a marked reduction in PAS positive cells, and 7 showing an equally marked increase. From these results it seems that the PAS reaction does not identify a sub‐type of ALL or mark the degree of differentiation of a given case. It could be indicative of a specific stage of the lymphoblast mitotic cycle.