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An Intestinal Receptor for Heme
Author(s) -
Gräsbeck Ralph,
Kouvonen Ilkka,
Lundberg Magaretha,
Tenhunen Raimo
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02845.x
Subject(s) - heme , chemistry , biochemistry , enzyme
Porcine upper small intestine took up radioactive heme in vitro. The binder was localised to the brush borders, was solubilized with Triton X‐100 and bound heme with high affinity. The binding was inhibited with non‐radioactive heme but not with FeSO 4 , and control experiments indicated that it was not any of the known heme binders or aggregated heme. The binding factor could also be solubilized from human duodenum.