Premium
A Platelet Defect in a Patient with Eosinophilic Leukaemia: Absent Ristocetin‐Induced Platelet Aggregation Associated with a Reduced Platelet Sialic Acid Content
Author(s) -
Wautier J. L.,
Souchon H.,
Dupuis D.,
Caen J. P.,
Nurden A. T.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02808.x
Subject(s) - ristocetin , platelet , sialic acid , thrombin , chemistry , glycoprotein , polyacrylamide gel electrophoresis , platelet aggregation , medicine , biochemistry , endocrinology , enzyme
Platelets from a patient with eosinophilic leukaemia were not aggregated by ristocetin. The defect was not corrected by normal human plasma and was due to a platelet abnormality. The patient's platelets also showed a diminished sensitivity to aggregation by bovine factor VIIIVWF. The defect was not associated with a prolonged bleeding time. No abnormalities were detected in ADP, collagen or thrombin‐induced platelet aggregation. Biochemical studies showed that the platelets were deficient in sialic acid. This deficiency was associated with a reduced staining for glycoprotein I following SDS‐polyacrylamide gel electrophoresis. The results suggest an acquired platelet surface abnormality.