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B‐Cell Acute Lymphatic Leukaemia: Immunoglobulin Synthesis, Morphology and Clinical Features
Author(s) -
Smith J.,
Newell D. G.,
Gordon J.,
Anson A.,
Roath S.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02804.x
Subject(s) - antibody , receptor , surface immunoglobulin , cell , complement receptor , lymphatic system , pathology , immunology , complement (music) , biology , b cell , complement system , medicine , biochemistry , complementation , gene , phenotype
A detailed case study of a B cell acute lymphocytic leukaemia (ALL) is described. Ultrastructurally the neoplastic cells resembled other cases of ALL studied. The majority of the neoplastic cells had detectable surface IgGλ and receptors for Feγ while a minority of the cells had receptors for the C3 component of complement. Neoplastic cell preparations were able to synthesize IgGλ with a surplus of free λ chains. This case did not respond to treatment, and death ensued within 36 h of presentation. The clinical and laboratory findings are discussed with respect to other cases of ALL.