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Transient Acquired Resistance to the Coumarin Anticoagulants Phenprocoumon and Acenocoumarol
Author(s) -
Wolff Frederik A. de,
Cate Jan W. ten
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02746.x
Subject(s) - phenprocoumon , acenocoumarol , coumarin , medicine , anticoagulant , diathesis , pharmacology , anesthesia , surgery , warfarin , chemistry , atrial fibrillation , immunology , organic chemistry
A 62‐year‐old man developed resistance to coumarin congeners during treatment with phenprocoumon (Marcoumar®) and acenocoumarol (Sintrom®), requiring at least triple the usual therapeutic dose and plasma concentration of phenprocoumon for satisfactory anticoagulation. After 8 months on this high dosage, the patient suddenly developed haemorrhagic diathesis. The medication was therefore discontinued. The resistance could not be ascribed to impaired absorption or enhanced metabolism.