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Altered Erythrocyte Membrane Protein Phosphorylation in an Unusual Case of Hereditary Spherocytosis
Author(s) -
Boivin Pierre,
Delaunay Jean,
Galand Colette
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02700.x
Subject(s) - hereditary spherocytosis , spectrin , phosphorylation , spherocytosis , phosphatase , erythrocyte membrane , epb41 , membrane protein , band 3 , chemistry , incubation , membrane , nucleotide , biochemistry , biology , microbiology and biotechnology , genetics , gene , immunology , splenectomy , spleen , cytoskeleton , cell
Membrane protein phosphorylation was examined in several members from a family with an unusual form of hereditary spherocytmis. After incubation of membrane ghosts with (γ‐ 32 P) ATP, the phosphorylation of spectrin component II was diminished both in the absence and presence of CAMP. In the presence of this nucleotide, the phosphorylation of components IV 5 and IV 8 was also decreased. Along with a previously reported alteration of a membrane neutral phosphatase in this family, these abnormalities remove the present condition from the usual form of hereditary spherocytosis.