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The Effect of Acetyl Salicylic Acid and Dipyridamole on Thromboembolic Complications in Splenectomized Patients with Myelofibrosis
Author(s) -
Hansen Mogens Sandbjerg,
Christensen Bjarne Egelund,
Jønsson Viggo
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02689.x
Subject(s) - myelofibrosis , dipyridamole , salicylic acid , platelet , medicine , gastroenterology , platelet aggregation , thromboembolic disease , pharmacology , thrombosis , biochemistry , chemistry , bone marrow
The effect of combined treatment with acetyl salicylic acid and dipyridamole on thrombotic phenomena was studied in splenectomized patients with an aggressive form of myelofibrosis. 3 of these patients had thrombotic episodes, shortened platelet survival and an abnormal platelet aggregation pattern. The treatment with anti‐platelet drugs resulted in a decreased platelet utilization as evidenced by clinical improvement and an increasing platelet concentration.