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Isoenzymatic Study of Leucocytic Acid Phosphatase in Haematologic Diagnosis
Author(s) -
Lafuente Rosario,
Woessner Soledad,
SansSabrafen J.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb02686.x
Subject(s) - biology , acid phosphatase , pathology , immunology , differential diagnosis , biochemistry , enzyme , medicine
Isoenzymatic study of leucocytic acid phosphatase under normal conditions identifies 3 isoenzymatic bands, which exhibit a noticeable cell specificity. Band 2 is granulocytic, band 3 lymphocytic and band 4 monocytic in origin. Pathologic deviations in the isoenzymatic pattern are both qualitative and quantitative. For some diseases such as chronic lymphocytic leukaemia there: is a well‐defined, differential pattern according to immunological B‐ or T‐cell origin. The more significant qualitative aspects are related to the appearance of abnormal bands, especially band 3b, indicating blastic cellularity, and 5, corresponding to hairy cells. The isoenzymatic analysis of acid phosphatase activity is a simple haematdogic complementary test, particularly useful in the differential diagnosis of lymphoproliferative disorders with peripheral blood manifestations.