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Successful Treatment with Prednisone of Graft‐Versus‐Host Disease in an Allogeneic Bone‐Marrow Transplant Recipient
Author(s) -
Groth CarlGustav,
Gahrton Gösta,
Lundgren Göran,
Möller Erna,
Pihlstedt Peter,
Ringdén Olle,
Sundelin Pär
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb00428.x
Subject(s) - prednisone , medicine , methotrexate , bone marrow , eosinophilia , graft versus host disease , graft vs host reaction , disease , bone marrow transplantation , surgery , immunology , gastroenterology
A 51‐year‐old patient with aplastic anaemia in whom a successful allogeneic bone‐marrow transplantation had been performed developed acute graft‐versus‐host disease in spite of prophylactic administration of methotrexate. There was severe liver injury but no involvement of the skin or intestines. When prednisone therapy was introduced the fever and the eosinophilia disappeared and liver damage was rapidly reversed. There was no haematological impairment. It would seem warranted to consider a wider use of prednisone in the treatment of acute GVHD in human recipients of allogeneic bone‐marrow.