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Acquired von Willebrand's Syndrome and Ehlers‐Danlos Syndrome Presenting with Gastro‐Intestinal Bleeding
Author(s) -
Clough Virginia,
MacFarlane I. A.,
O'Connor J.,
Wood J. K.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb00424.x
Subject(s) - medicine , ehlers–danlos syndrome , coagulation , tranexamic acid , gastrointestinal bleeding , von willebrand factor , cimetidine , gastroenterology , surgery , blood loss , platelet
The clinical and laboratory findings in a patient with severe gastrointestinal bleeding and the Ehlers‐Danlos syndrome are described. Coagulation studies and a lack of history of previous haemorrhage were consistent with a diagnosis of acquired von Willebrand's syndrome. His response to treatment with blood transfusion, Factor VIII, cimetidine, tranexamic acid and cyclophosphamide is described. Family studies revealed other members with Ehlers‐Danlos syndrome but normal coagulation.