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Acute Promyelocytic Leukaemia: Further Evidence of the Differentiation‐Linked Expression of la‐Like (p28,33) Antigens on Leukaemic Cells
Author(s) -
McVerry B. A.,
Goldstone A. H.,
Janossy G.
Publication year - 1979
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1979.tb00400.x
Subject(s) - antigen , haematopoiesis , acute promyelocytic leukemia , immunology , acute leukemia , leukemia , biology , cancer research , cell culture , medicine , stem cell , microbiology and biotechnology , genetics , retinoic acid
Patients with acute non‐lymphoblastic leukaemia were studied to determine if the presence of la‐like antigens on leukaemic cells was related to the maturity of a leukaemic cell line. Ia‐like antigens were present in the majority of acute myeloblasts and myelomonoblastic leukaemias. 4 patients with acute promyelocytic leukaemia were la‐negative. This finding suggests that la‐like antigens reflect normal differentiation linked events in haemopoiesis. The presence of Ia‐like antigens on leukaemic cells did not alter the patient's response to chemotherapy.