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A Near Haploid Clone: 24, XY, t (9; 22) (q34; q11) from a Patient in Blast Crisis of Chronic Myeloid Leukaemia
Author(s) -
Daniel A.,
Francis S. E.,
Stewart L. A.,
Barber S.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02499.x
Subject(s) - clone (java method) , blast crisis , bone marrow , chronic myeloid leukaemia , ploidy , myeloid , biology , chromosome , pathology , medicine , immunology , cancer research , genetics , gene
Chromosome studies on bone marrow in a patient with chronic myeloid leukaemia (CML) revealed a mosaic picture with a dominant clone of 24, XY, t (9; 22) (q34; q11). This corresponded to a preponderance of minute blasts in smears of bone marrow aspirate. It is suggested that a haploidy event rather than progressive hypodiploid loss, is responsible for the genesis of the miniature blast cells.