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In Vitro Medullary Granulocytic Progenitor (CFU C ) Cultures from 6 Cases of Granulocytopenias
Author(s) -
Parmentier C.,
Tchernia G.,
Subtil E.,
Diakhate L.,
Morardet N.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02490.x
Subject(s) - medullary cavity , progenitor , in vitro , progenitor cell , cfu gm , biology , microbiology and biotechnology , stem cell , anatomy , genetics
Medullary granulocyte progenitor (CFU C ) cultures were grown in vitro from samples taken from 6 patients with toxic granulocytopenia caused by either thiamphenicol, cephalothin or amidopyrine and who are now apparently cured. A decrease in the medullary concentration of CFU C has been observed and a calculated estimate shows that there was a decrease in their absolute number. A decrease in the number of CFU C per 10 5 metamyelocytes suggests a possible compensation by mitotic amplification between the stem cell and the differentiated cells. Two successive cultures have shown that the course of such medullary cultures is variable. The existence of medullary anomalies before drug toxicity as well as the practical consequences of the contrast between the apparent cure and the decrease in CFU C are discussed.