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Interrelationships between Blood Volume, Venous Haematocrit and Renal Failure in Myelomatosis
Author(s) -
Hansen Ole Paaske,
Drivsholm Aage
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02483.x
Subject(s) - renal function , venous blood , plasma volume , urology , medicine , blood volume , creatinine , endocrinology , body weight , gastroenterology
Plasma volume (PV), venous haematocrit (PCV) and total blood volume (BV) were measured in 24 patients with untreated myelomatosis using Evans Blue dye technique and PCV corrected for ‘trapped’ plasma and body/venous haematocrit ratio. The state of renal insufficiency was expressed as a serum creatinine and a glomerular filtration rate using 51 CrEDTA clearance. The total BV was normal in all but 3 patients, whereas the PCV was subnormal with an average value of 0.267. Consequently, the PV was expanded with an average value of 25 % compared to normal values. The PV was positively corrected to the concentration of gammaglobulin in serum. The 3 patients with increased BV caused by an increased PV had subnormal red blood cell mass and thus a partial haemo‐dilution anaemia only. A highly significant correlation was found between renal clearance and PCV and between renal clearance and the indirectly measured red blood cell mass, respectively (P < 0.001). The data demonstrate that renal failure in myelomatosis is associated by an increase in PV and a decrease in PCV without any change in total BV. No correlation was found between the degree of renal insufficiency and body/venous haematocrit ratio. Thus, the major determining factor in prediction of PCV and red blood cell mass was the glomerular filtration rate. The results are in agreement with the assumption of a nephrogenic pathogenesis in anaemia of myelomatosis.