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The Exchangeable Splenic Platelet Pool in Response to Intravenous Infusion of Isoprenaline
Author(s) -
Fredén Krister,
Olsson LarsBertil,
Suurküla Madis,
Kutti Jack
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02465.x
Subject(s) - isoprenaline , platelet , spleen , chemistry , medicine , endocrinology , stimulation , microgram , anesthesia , biochemistry , in vitro
8 healthy volunteers and 4 asplenic subjects, in whom autologous platelets had been labelled with radioactive sodium chromate, received i.v. infusions of isoprenaline in a dose of 0.03 μg × kg –1 × min –1 over a period of 6 min. In the former group these infusions caused a significant decrease in the concentration of labelled as well as unlabelled platelets in the peripheral blood. Body surface countings showed that a significant increase in the count rate over the spleen occurred concomitantly with the decrease in the circulating platelet‐bound radioactivity (PBR). In the group of asplenic subjects no change in PBR occurred. It is concluded that adrenergic beta‐receptor stimulation causes a transitory trapping of platelets in the exchangeable splenic platelet pool.