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CLL and Diffuse Histiocytic Lymphoma in One Patient: Clonal Proliferation of Two Different B Cells
Author(s) -
Splinter T. A. W.,
Noorloos A. Bomvan,
Heerde P.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb01551.x
Subject(s) - histiocyte , bone marrow , lymphoma , lymph node , pathology , surface immunoglobulin , monoclonal antibody , monoclonal , chronic lymphocytic leukemia , medicine , diffuse large b cell lymphoma , lymphoproliferative disorders , antibody , immunology , b cell , leukemia
A case report is presented of a 77‐year‐old woman suffering from a composite lymphoma, known as Richter's Syndrome, consisting of chronic lymphocytic leukaemia (CLL) and diffuse histiocytic lymphoma. Light‐microscopic investigation revealed the presence of CLL cells in the blood and bone marrow and a combination of CLL cells and large immunoblastic cells in the lymph node. Immunological investigation showed that both malignant cell types were B cells. The CLL cells carried a monoclonal surface immunoglobulin (S‐Ig) μΛ, and the immunoblastic cells had a monoclonal S‐Ig μk. These findings indicated that both clonal lymphoproliferative diseases were probably derived from different tumour stem cells.