Premium
Detection of Antiplatelet Antibody in Immune Thrombocytopenic Purpura
Author(s) -
Pascual Cherry Jo,
Romano Egidio
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb00378.x
Subject(s) - thrombocytopenic purpura , antibody , platelet , immune system , immunology , purpura (gastropod) , medicine , antigen , staphylococcus aureus , biology , bacteria , ecology , genetics
Two methods have been developed for the detection of antiplatelet antibodies in immune thrombocytopenic purpura (ITP). The first, a competitive RIA, is highly sensitive, reproducible and allows quantitation of platelet associated immunoglobu‐lins (PAI) and specifically adsorbed antiplatelet antibodies from serum of patients with ITP. The second procedure developed is a simple and rapid qualitative test, where antiplatelet antibodies are detected through the formation of rosettes of protein A producing Staphylococcus aureus with sensitized human platelets.