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Chronic Lymphocytic Leukaemia with Subsequent Development of Multiple Myeloma
Author(s) -
PedersenBjergaard Jens,
Petersen Hans Draminsky,
Thomsen Mogens,
Wiik Allan,
WolffJensen Jacob
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb00361.x
Subject(s) - multiple myeloma , antibody , bone marrow , chronic lymphocytic leukemia , medicine , immunology , myeloma protein , immunofluorescence , pathology , leukemia
In a patient with chronic lymphocytic leukaemia, two M components of the IgGk and IgGλ classes were demonstrated in the serum at the time of diagnosis. The patient was first followed without treatment; after 18 months multiple myeloma developed. At that time, immunofluorescence study of lymphocytes of the peripheral blood showed mainly membrane‐bound immunoglobulins (S‐Ig) of the IgGk class. The bone marrow disclosed a definite predominance of plasma cells with cytoplasmic IgGλ, suggesting that the two B cell‐derived diseases had arisen from two different cell clones. During the development of multiple myeloma, the serum concentration of the M component IgGλ increased. Concurrently, the M component of IgGk gradually disappeared from the serum, and the concentrations of the normal immunoglobulins IgA and IgM declined. Following cytostatic treatment, the concentration of the myeloma‐derived M component IgGλ was halved and simultaneously the M component IgGk reappeared in the serum. To our knowledge, this case is the second reported of chronic lymphocytic leukaemia and multiple myeloma indicating development of the two diseases from different cell clones, and the first reported case with myeloma‐induced suppression of M‐com‐ponent secretion from malignant cells.