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Morphological and Immunological Similarity of the Monocytes from Pure and Mixed Monocytic Leukaemias
Author(s) -
Cawley John C.,
Burns Gordon F.,
Worman Colin P.,
Flemans Roger J.,
Sibbald Robert,
Barker Christopher R.,
Roberts Bryon E.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb00358.x
Subject(s) - phagocytosis , receptor , monocyte , immunology , monocytic leukemia , antibody , acute monocytic leukemia , biology , sensitization , pathology , medicine , leukemia , biochemistry
Morphological and immunological marker data on a patient with ‘pure’ monocytic leukaemia are presented and compared with those of 6 cases of clearly mixed myelo‐monocytic leukaemia with a variable monocytic component. In all patients studied, the leukaemic monocytes expressed a receptor for the Fc of IgG, and IgG sensitization markedly enhanced phagocytosis of ox erythrocytes. A variable, but lower, percentage of the leukaemic monocytes had a receptor for mouse C3, but the cells uniformly lacked surface immunoglobulin and receptors for the Fc of IgM and for unsensitised mouse erythrocytes. Cytochemical and ultrastructural study also showed no clear difference between the monocytes of the ‘pure’ and mixed monocytic leukaemias. This report therefore lends no support to the concept of distinct types of monocytic leukaemia.