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Enhancing Effect of Levamisole on the Phagocytic Activity of Human Neutrophil Polymorphonuclear Leucocytes in vitro
Author(s) -
Molin Lars,
Stendahl Olle
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02724.x
Subject(s) - levamisole , in vitro , polymorphonuclear leukocyte , phagocytosis , immunology , opsonin , granulocyte , neutrophile , chemistry , microbiology and biotechnology , biology , biochemistry
The effect of levamisole on the phagocytic activity of normal human polymorphonuclear neutrophil leucocytes has been studied in vitro. In concentrations comparable with the serum levels obtained in treatment with levamisole perorally, the engulfment of heat‐killed yeast cells is moderately but significantly increased. It is shown that levamisole can only stimulate phagocytosis of adequately opsonized particles. The action of the drug is still unknown but appears to be directly linked to the phagocytic cell.