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The Investigation of Collagen Induced Platelet Aggregation by the Screen Filtration Pressure Technique
Author(s) -
Chater B. V.,
Sanderson J. H.
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02343.x
Subject(s) - filtration (mathematics) , platelet aggregation , platelet , chemistry , biophysics , biomedical engineering , composite material , materials science , medicine , mathematics , biology , statistics
A modification of the screen filtration pressure technique has been developed to allow platelet response to collagen to be measured. Using a commercial collagen suspension this method has been found to be both simple to perform and to give highly reproducible results. Changes in platelet response to collagen after administration of acetylsalicylic acid were clearly detected and this suggests that collagen screen filtration pressure may provide a sensitive method for evaluating the effect of platelet release inhibiting drugs.