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Distribution of B, T, and O Lymphocytes in Blood and Tissues of Normal Humans Reflecting a Kinetic Model
Author(s) -
Jønsson Viggo,
Christensen Bjarne Egelund
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02329.x
Subject(s) - lymph , bone marrow , lymphocyte , pathology , lymphatic system , afferent , biology , medicine , immunology , anatomy
The occurrence of the lymphocyte subpopulations T E , B Fo , B C3 , B Fc + C3 , B Ig , and O ‐ , percentage as well as absolute, was studied in lymphocyte suspensions from tonsils, abdominal lymph nodes, spleens, bone‐marrow aspirates, and at the same time in venous blood. The absolute lymphocyte content (number of lymphocytes per g tissue) was highest in the abdominal lymph nodes, lower in the spleens and tonsils, and lowest in the blood. T E lymphocytes were found in the significantly highest percentage, 60%, in the blood. B lymphocytes, comprising B Fc+C3 plus B Ig , were present in the highest percentage in the bone marrow: 74%. Tonsils, spleens, and abdominal lymph nodes contained fewer B lymphocytes, and the blood fewest: 39%. A significant correlation was found only between the absolute numbers of T and B lymphocytes. A relationship between the absolute number of T lymphocytes and the total number of B lymphocytes as well as fractions thereof was thus demonstrated in the various tissues and in the blood and also between the blood and the tissue. O ‐ lymphocytes were found in bone marrow, lymph nodes, and spleens, apparently as markerless precursors of other subpopulations. The main conclusion of the study is: In the lymphocytokinetic system the T lymphocytes must play a guiding role as an afferent vector, trigging the B fractions which thus constitute the efferent vector of the system.