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The Effect of Vincristine on Haemoglobin Synthesis
Author(s) -
BenBassat Isaac,
Mozel Miriam,
Mark Ziva,
Ramot Bracha
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02110.x
Subject(s) - vincristine , vinca , globin , chemistry , ribosome , pharmacology , puromycin , hemoglobin , biochemistry , medicine , biology , protein biosynthesis , chemotherapy , cyclophosphamide , rna , gene
Vincristine in a concentration of 0.5 and 4 times 10 −5 M causes a decrease of 16 % and 73 % respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration the α/β ratio is significantly lower than the normal ratio of unity and is 0.83 ± 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.