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Prevention of Plasmin Autodigestion by Human Plasma α 2 ‐Macroglobulin
Author(s) -
Toki Naotika,
Ishihara Hiroshi,
Yamura Takuso
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02107.x
Subject(s) - plasmin , chemistry , macroglobulin , alpha 2 macroglobulin , human plasma , substrate (aquarium) , biochemistry , enzyme , chromatography , biology , ecology
The autodigestion of plasmin in neutral solution at 37° C and prevention of plasmin autodigestion by methylamine were confirmed by using ϱ‐Tosyl‐L‐Arginine‐Methyl ester as a substrate of plasmin. The autodigestion of plasmin was prevented by human plasma α2‐macroglobulin which has been reported as an antiplasmin of immediate and reversible type, but was not prevented by α1‐antitrypsin which has been reported as an antiplasmin of slow and irreversible type.