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Hypoimmunoglobulinaemia and Aplastic Anaemia
Author(s) -
Mir M. A.,
Geary C. G.,
Delamore I. W.
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02102.x
Subject(s) - aplastic anemia , immunology , antibody , immune system , medicine , disease , bone marrow
Serum immunoglobulin levels were estimated in 19 patients with aplastic anaemia. Although the mean levels for IgG, IgA and IgM for the group as a whole were within the normal range, 8 individual cases showed low levels of one or more immunoglobulin class, suggesting a disturbance in immunoglobulin production. One of these patients had a thymoma, and another positive tests for anti‐nuclear factor, but there was no evidence of auto‐immune disease in the others. It is suggested that ‘aplastic anaemia’ may sometimes be a disease due to injury of a stem cell subserving both haemopoietic and immunological function.