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A Case of T‐cell Lymphoma with Sézary Cells in the Blood and Bone Marrow Accompanied by Peripheral T and B Lymphocytosis
Author(s) -
Manthorpe Rolf,
Jønsson Viggo,
Christensen Bjarne Egelund,
Hesselvik Margaretha,
Egeberg Jørn,
Videbæk Aage
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02099.x
Subject(s) - lymphocytosis , mycosis fungoides , bone marrow , pathology , medicine , lymphoma , peripheral blood , immunology
A case of T‐cell lymphoma occurred in a man, aged 66, whose symptoms started as itching and the appearance of 1–2 cm indurated plaques with central pustules on the skin of the trunk and face. A few months later generalized lymphomas and splenomegaly were present. Investigations of the lymphocytic subpopulations in situ in fresh frozen sections of lymphomas and skin showed only T cells. Samples of blood and bone marrow disclosed lymphocytosis and Sézary cells. Both T and B lymphocytes were definitely increased in the blood. The value of tissue studies in analyzing lymphocytic subpopulations is emphasized as a differential diagnostic aid in classifying lymphomas. A relationship between the T‐cell neoplasia and the T and B lymphocytosis to mycosis fungoides and the Sézary syndrome is discussed.