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DNA Synthesis in Unstimulated Blood Lymphocytes of Patients with Untreated Malignant Lymphomas or Other Malignant Tumors
Author(s) -
Heier Hans Erik,
Godal Tore
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02084.x
Subject(s) - thymidine , malignant lymphoma , peripheral blood mononuclear cell , dna synthesis , lymphoma , lymphocyte , peripheral blood , medicine , pathology , dna , malignant disease , disease , immunology , biology , cancer , in vitro , biochemistry
Blood lymphocyte DNA synthesis, as expressed by 24‐h uptake of 3 H‐thymidine in culture of mononuclear peripheral blood leucocytes has been recorded prior to treatment in 18 patients with Hodgkin's disease, 11 with non‐leukaemic lymphosarcoma, 13 with reticulosarcoma and 20 with various solid tumors, and compared to 37 normal control subjects. The 3 H‐thymidine uptake was significantly increased in all the patient groups, but no significant difference existed between them. Increased uptake of 3 H‐thymidine did not appear to correlate with the degree of dissemination in any of the patient groups or with the presence or absence of general symptoms in malignant lymphoma. It is concluded that increased DNA synthesis in peripheral blood lymphocytes is a feature not limited to Hodgkin's disease, but found in non‐Hodgkin malignant lymphomas and other malignancies to about the same extent.