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Immunologic Similarities of Thrombopoietin from Different Sources
Author(s) -
McDonald T. P.,
Cottrell Marilyn,
Nolan Chris,
Walasek Otto
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02077.x
Subject(s) - thrombopoietin , antiserum , bioassay , immunoassay , haemagglutination inhibition , biology , urine , kidney , immunology , urinary system , antibody , endocrinology , microbiology and biotechnology , serology , stem cell , genetics , haematopoiesis
Thrombopoietin (TSF) has been detected in kidney cell culture media and human urine fractions by both a bioassay and an immunoassay using antisera raised against TSF‐rich kidney cell culture medium and human urinary thrombopoietin. Both antisera cross‐reacted with the 2 sources of TSF and gave essentially the same results in the HAI assay, a finding that suggests similarities in immunologic determinants of these 2 thrombopoietin preparations.