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Antifactor Xa Activity in Thrombophilia Studies in a Family with At‐III Deficiency
Author(s) -
ØDegård Ole Rasmus,
Abildgaard Ulrich
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb02076.x
Subject(s) - thrombosis , antithrombin , family history , thrombophilia , heparin , medicine , immunology , gastroenterology
Antithrombin III (At‐III) concentration and amidolytic assays reflecting functions of the At‐III molecule were studied in members of a family with a strong tendency to thrombosis. Antifactor Xa and heparin cofactor activity closely paralleled the At‐III concentration. In all individuals with a history of thrombosis At‐III concentration was about 50% of normal. The clinical features and causes of death are briefly reviewed. Mean age in deceased family members with a tendency to thrombosis was 55 years, in members with no history of thrombosis it was 65 years.