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Atypical Surface Marker Characteristics in a T‐Cell Lymphoma
Author(s) -
Janossy G.,
McVerry B. A.,
Goldstone A. H.,
Souhami R. L.,
Cawley J. C.,
Thompson D. S.
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01493.x
Subject(s) - lymphoma , antiserum , acid phosphatase , surface immunoglobulin , antibody , cell , esterase , phenotype , biology , pathology , microbiology and biotechnology , chemistry , b cell , immunology , enzyme , biochemistry , medicine , gene
A case of T‐cell lymphoma with an unusual phenotype is described. The majority of malignant tumour cells did not form E‐rosettes, and lacked surface immunoglobulin but reacted with an antiserum to T cells and thymocytes. Localised acid phosphatase and non‐specific alpha naphthol acid esterase activities and a prominent, convoluted, nuclear pattern in some neoplastic cells also supported the T cell derivation. The results demonstrate the importance of using a panel of markers for identification of the cellular derivation of some lymphomas.