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Studies on Human Preleukaemia
Author(s) -
Hast Robert,
Reizenstein Peter,
Jores Sylvia
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01485.x
Subject(s) - erythroblast , bone marrow , labelling , medicine , human bone , pathology , chemistry , endocrinology , andrology , erythropoiesis , anemia , biochemistry , in vitro
In 34 patients with aregenerative anaemia and hypercellular bone marrow, a condition earlier suggested to be of a preleukaemic nature, erythroblast thymidine labelling indices (LI) were significantly decreased, as would be expected in preleukaemia. The 59 Fe erythrocyte incorporation after 2 weeks was generally low. The 59 Fe plasma clearance was fast in 22 of 31 patients, normal in 5 and moderately prolonged in 4. These 4 patients had a low relative number of erythroblasts in the marrow. A significant relationship between the marrow erythroblast number and the 59 Fe plasma clearance could be demonstrated. Cases with an increased number of myeloblasts in the marrow did not differ significantly from the rest in LI and iron incorporation.