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Basophilic Differentiation of Chronic Myelogenous Leukaemia Cells in Vitro
Author(s) -
Miyoshi I.,
Uchida H.,
Tsubota T.,
Kubonishi I.,
Hiraki S.,
Kitajima K.
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01481.x
Subject(s) - basophilia , basophilic , in vitro , chronic myelogenous leukemia , pathology , biology , immunology , medicine , leukemia , biochemistry
Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed an increased proportion of mature basophils at about 3 weeks and most cultures consisted predominantly of mature basophils at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.