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Transfer of Iron from Ferastral® and other Organic Complexes to Transferrin as Measured by Reticulocyte Uptake
Author(s) -
SPEYER BARBARA E.,
DONEY VALERIE J.,
FIELDING JACK
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01240.x
Subject(s) - reticulocyte , transferrin , chemistry , biochemistry , messenger rna , gene
The transfer of iron from the iron carbohydrate complexes, Ferastral®, Imferon®, and Jectofer®, and from ferric chloride has been studied by the effect of such transfer in reducing reticulocyte uptake of 59 Fe from labelled transferrin. There are plasma factors which augment the transfer of iron from complex to transferrin. The pattern of transfer from Ferastral and from Imferon are similar: at concentrations of 5000 μg/100 ml and 1250 μg/100 ml in plasma these complexes transfer about 0.8% and 1.7%, respectively. Jectofer transfers about four times these amounts under similar conditions. In the case of Ferastral there is evidence of an equilibrium between transferrin‐bound and Ferastral‐bound iron. The characteristics of Ferastral assessed in this way suggest that it may prove suitable for therapeutic use as a total dose infusion.