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Metabolic Studies of Iron‐poly (sorbitol‐gluconic acid) complex, Ferastral®
Author(s) -
REIZENSTEIN PETER
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01231.x
Subject(s) - gluconic acid , sorbitol , iron deficiency , chemistry , metabolism , medicine , biochemistry , endocrinology , anemia
The metabolism of iron‐poly (sorbitol‐gluconic acid) complex (Ferastral®) was studied in 6 blood donors with latent iron deficiency and 13 patients with manifest iron deficiency anaemia. Between 125 and 1 000 mg of iron were injected. In latent deficiency an average of 19% of the dose given was excreted during the first two weeks. The corresponding figure for patients with manifest iron deficiency was 11%. An average of 8% of the dose was retained at the site of injection after 40 days. In the two groups, respectively, 61% (range 47%–70%) and 58% (range 24%–86%) of the iron retained was incorporated into red cells after 40 days, which is judged to be quite satisfactory. Some local side effects were observed.