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Distribution of the Carbohydrate Polymer in 14 C‐labelled Iron‐poly (sorbitol‐gluconic acid) complex after Intramuscular Administration in Normal and Anaemic Rats
Author(s) -
GAGNERMILCHERT INGALILL,
LINDVALL SVEN,
RYDELL GUNILLA
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01227.x
Subject(s) - gluconic acid , sorbitol , chemistry , urine , carbohydrate , distribution (mathematics) , chromatography , isoelectric focusing , biochemistry , enzyme , mathematical analysis , mathematics
The carbohydrate polymer in an iron‐poly (sorbitol‐gluconic acid) complex was prepared by using uniformly labelled 14 C‐sorbitol or 14 C‐gluconic acid. The distribution of these complexes 7, 14 and 28 days after administration has been followed in non‐anaemic and anaemic rats. Most of the 14 C from the labelled complexes was found in the expired CO 2 , faeces and urine. Twenty‐eight days after injection of 14 C‐labelled Ferastral®, less than 13% of the given dose of either 14 C‐sorbitol or 14 C‐gluconic acid labelled preparation could be found in the body. There was no specific accumulation of 14 C in any organ except in the bones, where 3% of the given dose could be seen 28 days after 14 C‐gluconic acid labelled Ferastral to both non‐anaemic and anaemic animals.