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The Haemostatic Effect of 51 Cr‐Labelled Blood Platelets An Experimental Study in the Rabbit
Author(s) -
Björnson J.,
Aursnes I.
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01203.x
Subject(s) - platelet , medicine , bleeding time , rabbit (cipher) , blood transfusion , whole blood , chemistry , anesthesia , surgery , platelet aggregation , statistics , mathematics
The haemostatic effect of 51 Cr‐labelled platelets was studied in 5 rabbits made thrombocytopenic (35,000/μl blood) by whole body ionizing irradiation. Bleeding times were recorded after standardized cuts on the inner side of the rabbit's ear, a method with an acceptable reproducibility. The animals were then each transfused with concentrates of labelled platelets from 2 healthy donor rabbits. This increased the platelet counts to about 2 times 10 5 /μl blood. Bleeding time values were markably prolonged before transfusion and became normalized when tested 1 and 4 h after transfusion. In 3 control experiments, where unlabelled platelet rich plasma was transfused to thrombocytopenic recipients, a similar shortening of the bleeding time was observed. It is concluded that 51 Cr‐labelled platelets retain haemostatic ability comparable to non‐labelled platelets, when circulating in a recipient animal.