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Cytogenetic Studies in Preleukaemia Using the G‐Banding Staining Technique
Author(s) -
Panani A.,
Papayannis A. G.,
Kyrkou K.,
Gardikas C.
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01200.x
Subject(s) - karyotype , chromosomal translocation , g banding , trisomy , chromosome , biology , marker chromosome , staining , genetics , chromosome analysis , cytogenetics , microbiology and biotechnology , pathology , medicine , gene
15 patients with preleukaemia were cytogenetically studied during the preleukaemic state by using the G‐banding staining technique. It was found that 9 patients had a completely normal karyotype, while the other 6 showed various chromosomal abnormalities, numerical (trisomies in 5 cases) and structural (deletion in 1 case and a marker chromosome in 1 case). The abnormalities concerned group C in all 6 cases, while group A was involved in 3 cases. G‐banding technique revealed that trisomy C affected the chromosomes nos 8 (2 cases) and 9 (3 cases); also a deleted chromosome 11 (11q‐) was identified in 1 case and a marker chromosome in 1, the origin of which was established as a translocation between chromosomes 3 and 6. The abnormalities of group A concerned chromosome no 3. The abnormalities found in our cases, using the G‐banding technique, were similar to those described in acute leukaemia.